Beilstein J. Org. Chem.2024,20, 470–478, doi:10.3762/bjoc.20.42
sulfur-containing ovalicin derivatives, along with three known analogues 3–5, were isolated and identified from the culture extract of Pseudallescheria boydii CS-793, a fungus obtained from the deep-sea coldseep sediments. Their structures were established by detailed interpretation of NMR spectroscopic
-spectrum inhibitory activities against several plant pathogens with MIC values ranging from 2 to 16 μg/mL.
Keywords: antimicrobial activity; coldseep; Pseudallescheria boydii; sesquiterpenoid; Introduction
Marine cold seeps are typical of chemosynthetically driven ecosystems, characterized by methane
antimicrobial activities [3][4].
As part of our continuing search for bioactive metabolites from deep-sea-derived fungi [3][4][5][6], the fungal strain Pseudallescheria boydii CS-793, which was obtained from sediments collected at the deep-sea coldseep area in the Northeast of the South China Sea, attracted
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Graphical Abstract
Figure 1:
Chemical structures of compounds 1–5 isolated from P. boydii CS-793.